Potts and new loan signing Mitchell start at Brisbane RoadTown boss Nathan Jones makes two changes to the side that beat Morecambe in the week.
Goalkeeper Jonathan Mitchell makes his debut in goal having joined on loan for the rest of the season from Derby.
Jake Howells is unavailable so Dan Potts makes his first appearance since the home defeat to Plymouth in October.
For hosts Orient, player/manager Kevin Nolan starts.
Town: Mitchell; O'Donnell, Potts, Cuthbert, Sheehan; Lee, Smith, McGeehan; McCourt; Marriott, Mackail-Smith.
Subs: Justham, Lawless, Benson, Green, Ruddock, Okuonghae, Pigott.
Orient: Cisak, Clohessy, Baudry, Palmer, Moore, Atangana, Brisley, Binnom-Williams, Simpson, Hunt, Nolan.
Subs: Grainger, Essam, McAnuff, Payne, Pritchard, Jahrarldo-Martin, Gnanduillet.
Ref: C. Breakspear