Town boss Rob Edwards makes two changes to the side that earned a draw with Nottingham Forest last time out with goal hero Luke Berry in from the start.
The midfielder is joined in the starting XI by former Tottenham winger Andros Townsend, who lines up at right-wing-back.
Joe Johnson, fresh from signing his new contract is among the substitutes, as is Fred Onyedinma in his first involved for the Hatters since the play-off final in May.
Town: Kaminski; Townsend, Doughty, Mengi, Burke, Kaboré; Mpanzu, Barkley, Berry; Chong, Morris.
Subs: Shea, Krul, Clark, Hashioka, Onyedinma, Johnson, Nelson, Piesold, Woodrow.
Tottenham: Vicario, Dragusin, Son, Bissouma, Maddison, Werner, Romero, Kulusevski, Porro, Sarr, Udogie.
Subs: Austin, Hojbjerg, Richarlson, Royal, Lo Celso, Johnson, Bentancur, Davies, van de Ven.
Referee: Jarred Gillett
