Henri Lansbury makes his first league start of the season as manager Nathan Jones makes five changes for the visit of Blackburn Rovers.
The midfielder came off the bench against Coventry City in midweek and starts alongside Allan Campbell and Jordan Clark in midfield.
Reece Burke, Tom Lockyer and Amari'i Bell return to the starting line-up as the boss switches up his defence looking for a third clean sheet of the season.
Cauley Woodrow makes up the fifth change, joining Carlton Morris up front. Harry Cornick and Elijah Adebayo both miss out through injury.
Alfie Doughty is in the matchday squad for the first time this season and could be in line for his Luton league debut off the bench.
Luton Town: Horvath; Bree, Burke, Lockyer, Potts (C), Bell; Lansbury, Campbell, Clark; Woodrow, Morris.
Substitutes: Isted, Watson, Onyedinma, Freeman, Osho, Jerome, Doughty.
Referee: Josh Smith