The Hatters crashed to a 7-0 defeat as Fulham wrapped up the Championship title at Craven Cottage tonight.
Manager Nathan Jones initially made six changes to his starting line-up from the 1-1 draw against Blackpool over a week ago.
Matt Ingram started in goal subject to terms of his emergency loan, with Harry Isted amongst the substitutes.
Fred Onyedinma was back to full fitness and started following the injury suffered against Cardiff City on the road, whilst there was a return to the starting line-up for Reece Burke in defence.
Henri Lansbury was due to join Scottish duo Allan Campbell and Robert Snodgrass in midfield, and up-front, Danny Hylton and Cameron Jerome started together - but Campbell had to drop out in the warm-up through injury, with Dan Potts coming into the starting line-up and Elliot Thorpe onto the bench.
Jordan Clark was also named on the bench having been absent from the matchday squad since victory against Hull in March.
Back in the midfield role he has played in recent weeks following the late change, Naismith was the first to have a shot on goal when his fourth-minute skidding effort from outside the box was pushed round the post by Marek Rodak.
Potts, pushed up from left-sided centre-half for the corner, then rose highest to meet Robert Snodgrass' right-wing delivery, but was off target with his header.
Hylton became the first player into ref Tim Robinson's notepad on ten minutes for a foul on Harrison Reed, but it didn't diminish the talismanic forward's determination to get in and around the home defenders as they attempted to play it out from the back.
Town really took the game to Fulham in the opening exchanges, and it wasn't until the 23rd minute that the hosts had their first sight of goal, Championship player of the year Aleksandar Mitrovic's snapshot saved well by Ingram at his near post.
Tom Lockyer was the next to see yellow for a foul on Mitrovic, then the Town's injury curse struck again when Onyedinma pulled up as he chased a ball from Lansbury down the right wing as they tried to spring a counter attack from defending the free-kick.
While the right wing-back was down awaiting treatment, Fulham broke and their captain, Cairney, crashed a shot into the roof of the Hatters' net to give the champions-elect a 28th-minute lead.
Peter Kioso was brought on to replace Onyedinma, and he was soon into the action as the Town tried to get back into the game, although Snodgrass and Lansbury quickly became players three and four into Robinson's book for quickfire fouls on Fabio Carvalho.
It was 2-0 in the 39th minute when Kenny Tete collected possession from Amari'i Bell's header clear and struck a rocket into the bottom corner from 25 yards.
The Cottagers came within an inch of making it three by the 43rd minute when Mitrovic dropped deep and played Harry Wilson into the box, but having rounded Ingram, the former Liverpool youngster saw his Welsh international team-mate Lockyer get back to clear his shot off the line.
It was 3-0 by the 54th minute when Carvalho started and finished a flowing move that involved Mitrovic and Wilson, and it was four just after the hour when Mitrovic netted his 42nd goal of the season.
Jones brought Admiral Muskwe on for Jerome in the 63rd minute, but within two minutes the fifth goal had gone in as Bobby De Cordova-Reid span in the box and placed his shot into the corner past Ingram.
Clark made his return from injury in place of Snodgrass, but by the 79th minute it was six when Jean Michael Seri hit a 30-yarder past Ingram into the bottom corner.
Mitrovic further compounded the Hatters' misery in added time as the Cottagers lifted the Sky Bet Championship trophy.
Goals: Cairney (29'), Tete (39'), Carvalho (54'), Mitrovic (62', 90+2'), De Cordova-Reid (65'), Seri (79')