The Hatters face Championship side Millwall at Kenilworth Road in the fifth round of the FA Cup.
The Lions beat Premier League opposition themselves in the fourth round, beating Aston Villa on Friday night.
The tie will take place on 16 and 17 February and this means our televised Blue Square Bet Premier fixture with Newport County, on Friday 15th February, will need to be re-arranged.
Ticket news will follow in due course.
Huddersfield Town or Leicester City v Wigan Athletic
MK Dons v Barnsley
Oldham Athletic v Everton
Luton Town v Millwall
Arsenal v Blackburn Rovers
Manchester City v Leeds United
Manchester United v Reading
Middlesbrough v Brentford or Chelsea