Town boss Rob Edwards makes three changes for Saturday’s local derby.
Carlton Morris returns to captain the side for his first appearance since scoring twice against Sheffield Wednesday.
With injuries robbing the Hatters of Teden Mengi and Reuell Walters, Tom Holmes comes in for his first start in Luton colours.
Tahith Chong also is back in the Town starting XI after he sat out the defeat at Sheffield United.
There are two familiar names back on the bench: goalkeeper Tim Krul and defender Daiki Hashioka appear in the Hatters squad for the first time this season.
Town: Kaminski, Doughty, Moses, Burke, McGuinness, Holmes, Krauß, Clark, Chong, Morris, Adebayo.
Subs: Krul, Woodrow, Nakamba, Mpanzu, Brown, Taylor, Hashioka, Nelson, Johnson.
Watford: Bachmann, Porteous, Pollock, Chakvetadze, Sema, Sissoko, Bayo, Ogbonna, Dele-Bashiru, Kayembe, Andrews.
Subs: Bond, Sierralta, Ince, Vata, Jebbison, Morris, Baah, Ebosele, Larouci.