Danish centre-back Mads Andersen makes his first start of the season replacing Daiki Hashioka in defence.
The last time the defender started for the Hatters saw the 1-0 defeat at home to Tottenham in October last year.
There are two changes on the bench with new signing Erik Pieters named among Rob Edwards’ substitutes as well as 17-year-old youth team defender Christian Chigozie.
Derby, won 4-0 last time out against Portsmouth, start with former Town skipper Sonny Bradley who captains the Rams this evening.
James Collins, who scored 72 goals for the Hatters in 183 games, is named among the County substitutes.
Town: Kaminski, Moses, Chong, Andersen, McGuinness, Holmes, Krauß, Clark, Brown, Morris, Adebayo.
Subs: Krul, Woodrow, Nakamba, Mpanzu, Pieters, Taylor, Nelson, Johnson, Chigozie.
Derby: Zetterstrom, Wilson, Bradley, Osborn, Yates, Phillips, Goudmijn, Jackson, Elder, Adams, Nelson.
Subs: Forsyth, Barkhuizen, Collins, Mendez-Laing, Harness, Ward, Blackett-Taylor, Vickers, Brown.
Referee: Andrew Kitchen