Town boss Matt Bloomfield makes four changes to the side that lost last weekend at Watford.
There are two changes in defence with Kal Naismith returning in defence and a full debut given to Christ Makosso.
Jordan Clark lines up in midfield in the place of Marvelous Nakamba and Jacob Brown lines up in attack alongside Carlton Morris.
Mark McGuinness is only fit for a place on the Hatters bench.
Town: Kaminski, Bell, Naismith, Makosso, Jones, Doughty, Clark, Walsh, Aasgaard, Brown, Morris.
Subs: Krul, Andersen, McGuinness, Adebayo, Alli, Fanne, Nelson, Nordås, Bowler.
Portsmouth: Schmid, Ogilvie, Poole, Pack, Bishop, Aouchiche, Dozzell, Swanson, Murphy, Ritchie, Hayden.
Subs: Archer, Towler, Potts, Yengi, O’Mahony, Gordon, Saydee, Bramall, Devlin.
Referee: Sam Allison