Drew Talbot signed for Luton Town in a £250,000 deal in January 2007 from Sheffield Wednesday as former Hatters boss Mike Newell looked to strengthen his options in attack. He made an immediate impact, making one and then scoring the winner against his old club at Kenilworth Road on his home league debut. Originally on the books of Barnsley, Talbot drifted out of football after injury but came back with Sheffield Wednesday's academy in the 2003/04 season. Often coming off the substitutes bench he scored goals in Wednesday's 2004/05 promotion season including one at Cardiff in the League One play off final against Huddersfield. The following season proved a disappointment for Drew as a back injury ruled him out. After his impressive first full season at Hillsborough, he was not to play again until September 2006, where he made a substitute appearance against Derby County in a 2-1 home defeat. During the January 2007 transfer window, Talbot signed a loan-contract with League One promotion-chasers Scunthorpe United before signing at Kenilworth Road.