Luton name an unchanged line-up from the team which lost 2-1 to Carlisle United in midweek.
That meant Ryan Charles was handed his home debut and partnered Paul Furlong in attack.
Oldham, suffering from a crippling injury crisis with 19 senior players out through injury, were only able to name a 15-man squad.
They handed a debut to goalkeeper Richard O'Donnell, who was signed on Friday on an emergency loan from Sheffield Wednesday.
Luton: Dean Brill, Chris Perry, David Bell, Richard Jackson, Lewis Emanuel, Keith Keane, Matthew Spring, Sol Davis, Paul McVeigh, Paul Furlong, Ryan Charles
Substitutes: Don Hutchison, Sam Parkin, Stephen O'Leary, Drew Talbot, Calvin Andrew
Oldham: Richard O'Donnell, Neil Eardley, JP Kalala, Stefan Stam, Jason Jarrett, Kelvin Lomax, Reuben Hazell, Gary McDonald, Chris Taylor, Deane Smalley, Leon Constantine
Substitutes: John Thompson, Matt Wolfenden, Ashley Kelly, Josh Bell
Referee: Mr R East
