The Ladies' first team put up a dogged fight against runaway league leaders Liverpool in the top versus bottom encounter.
The Town started positively with skipper Michelle Byrne coming close to celebrating her 21st birthday in style when she pushed the ball past the Reds' goalkeeper but a covering defender was able to clear to deny the Hatters the lead.
With Luton still suffering from absentees, the side put up a spirited show but finally went down 2-0 to a side containing no fewer than six internationals.
By comparison, the Town proudly fielded five players in the squad who were playing Under 16 youth football as recently as six months ago.
Elsewhere, the reserves moved into fourth spot in their league after defeating Tower Hamlets 4-1.
A powerful attacking performance produced goals two goals for Laura Day and one each for Leyah Maddix and Claire Howe who scored with a trademark free-kick.
The third team climbed into third spot with a comfortable victory over Wingate and Finchley 2-0 with goals from Nina Hale and Nicky Shepherd.
It was goals galore for both the Under 16s and Under 15s for the second consecutive week.
The Under 16s hammered Fairlands 9-1 with Holly Sheridan netting a hat-trick. There were also goals for Katie Davis, who scored twice, Mirella Tambini, Maisie Wyatt, Millie Glean and Terri Petit.
AFC Stevenage were the unfortunate side who were on the receiving end of the Under 15s' incredible 11-0 thumping.
Rachel Kosky netted a treble and there were doubles for Laura McGarry, Lydia Radley and Amy Nash. Jody Whitford-Stark and Yasmin Jones completed the rout.
There was deadlock at the top of the Under 13 table as Abby Kunert scored twice in a 2-2 draw away to Denham United.
The Under 10s continued their recent good form with a 3-1 away win at Harvesters. Claudia Attenborough scored twice with Tyler Trussell scoring the other goal.