A second-half blitz of four goals in seven minutes saw the Town blow away Gary Brabin's old club Southport as they went goal crazy at the Kenilworth Road end.
After a lacklustre first half in pouring rain, the Hatters equalised on the stroke of half-time through Adam Watkins on his full league debut, before a startling seven-minute period in the second period saw four goals and a red card as the visitors capitulated, just as they had done in this fixture last season.
Goals from Will Antwi, Robbie Willmott, and substitutes Amari Morgan-Smith and Danny Crow sealed three points for the Town in a five-star performance.
Brabin made three changes to the side that drew with Forest Green on Tuesday, handing a full league debut to Adam Watkins in midfield, and bringing in Willmott and Mark Tyler, both returning to match fitness. Ed Asafu-Adjaye, Matthew Barnes-Homer and goalkeeper Kevin Pilkington were dropped to the bench.
The Town will have started full of confidence after beating Southport 6-0 back in April, and could have taken the lead in the first minute. Willmott, returning to the starting line-up after his sparkling cameo on Tuesday, went close after 30 seconds. Watkins laid the ball wide to Willmott on the left, who cut inside and struck a clean low shot just wide of the near post from outside the area.
But disaster struck on eight minutes as Southport broke upfield after Aaron O'Connor
was disposed in the Town attack, and took an unexpected lead. Jake Howells was left exposed as Sandgrounders' captain Kevin Lee charged at him with the ball as the Hatters youngster struggled to mark both John-Paul Kissock to his right and Jonathan Brown to his left. The visiting attacker was able to execute a simple wall-pass around Howells, as Kissock squared for Brown to finish under Tyler in the Town goal.
As heavy rain fell on Kenilworth Road, Hatters spirits were dampened and the hosts struggled to get a grip on the game. A rare Town chance saw Southport's goalkeeper Tony McMillan get lucky on twelve minutes, as he did just enough to palm the wet ball clear after Willmott struck through the driving rain following a short corner.
Looking an altogether different proposition to the side that submitted to a 6-0 defeat in this fixture last season, Southport were showing great tenacity and work ethic in midfield.
The Town were seeing lots of possession, but time and time again Hatters midfielders were finding themselves surrounded by white shirts as the visitors chased and harangued Brabin's men.
On the half-hour mark the hosts were forced into a reshuffle when James Dance departed with a head injury. Crow entered the fray as central striker, as O'Connor moved out wide to Dance's right-wing position.
The change in personnel seemed to reinvigorate a rather lost-looking Town side, and the subdued Kenilworth Road crowd roared back to life when Watkins skipped past two Southport midfielders and hit a goal-bound left-foot shot that was deflected over for a corner. From the resultant flag-kick O'Connor came close after Antwi headed across goal.
Crow looked like he really meant business, and he came close to equalising for the Town on 38 minutes with a fine piece of skill. Keith Keane surged through the midfield and threaded a low, forward pass into the feet of Crow who had his back to goal. Holding off the visiting defender, the diminutive striker flicked the ball up and hit a lobbed volley on the turn that arched just over McMillan's crossbar.
And Watkins, who had shown great spirit to keep plugging away in the midfield through a difficult first-half period, got the equaliser the Town had been threatening with an exquisite solo goal in his first league start for the Hatters. Collecting the ball 30 yards from goal, he dribbled past two midfielders and placed a perfect low effort into the bottom right-hand corner from the edge of the area.
Antwi almost put the hosts in front on the brink of half-time with a firm header from an Alex Lawless cross, but McMillan was able to hold.
The teams went in level at the break, but the Hatters went down the tunnel with their tails up, having rallied and found some form towards the end of the half.
The Town's play had brightened with the weather, and as the sun came out at the start of the second half, the home side tried to build on the momentum they'd gained at the end of the first period.
O'Connor did well to fashion a chance for himself early on, but on his weaker left foot he could only drag the ball straight at McMillan.
O'Connor then left the field of play on the hour mark to be replaced by Amari Morgan-Smith for his first appearance since last season's visit to Histon, where he was on the scoresheet in a 4-0 win.
And the former Ilkeston forward almost scored immediately following his introduction, placing the ball just wide after being played into the area by the impressive Crow.
Crow went close himself moments later, dinking just over on the half-volley after finding space as Lawless played a perfect chipped through-ball into his path.
And as the Town pressed for a break-through, Southport were reduced to 10 men on 67 minutes as Steve Akrigg was sent off for a second booking. As the Hatters' young magician Watkins dribbled forward with intent, he changed direction and shaped to shoot, only to be brought down by Akrigg. On a booking already, Akrigg left referee A. Davies with no option but to show yellow then red.
With a one-man advantage, the Hatters piled forward in search of a second, which came on 71 minutes and sparked a frantic few minutes in which four goals would be scored with barely a moment's rest between each one.
Watkins weaved in and out of Southport defenders in the box and won a corner, which Willmott trotted across to take. The winger whipped in an in-swinger which found the head of Dean Beckwith, who flicked on for his central defensive-partner Antwi to head in for his first goal in Town colours.
And no sooner had the hosts taken the lead, they extended it further through substitute Morgan-Smith after 74 minutes. He won the ball on the left-wing and strode past two defenders as he worked his way into the area before firing into the back of the net courtesy of a slight deflection.
A fourth goal followed almost immediately, Morgan-Smith again popping up with the ball on the left and squaring for Willmott 20 yards out, who unleashed a cracking drive which a despairing McMillan was powerless to prevent from flying into the back of the net.
And rounding off a goal-crazy seven minutes, Crow compounded the visitors' misery with a fifth on 78 minutes, just seconds after Willmott's fourth, finishing with an easy header right under the crossbar from Curtis Osano's cross.
With the Town smelling more blood, Keane and Howells went close with speculative efforts, Morgan-Smith had a strong penalty shout turned down, and Crow was guilty of missing a couple of chances as Brabin's buoyant team ran rings around dejected Southport defenders.
But they had to be content with five in the end, as the referee called time on a remarkable match.
Few in the stadium would have anticipated such a turnaround midway through the first half, with the Town trailing and really struggling to impose themselves on the game.
However, inspired by the plucky Watkins, the Hatters did well to work their way into the match before half-time, before demolishing their opponents in the second period with a performance that demonstrated an encouraging ruthlessness in attack and resilience not to lose heart in a match that was far from plain-sailing in places.
With such momentum then next match can't come around quick enough for Brabin and his team, who travel to Mansfield on Tuesday night full of confidence.
For full coverage as always, be sure to join us here at www.lutontown.co.uk
For minute-by-minute analysis see below.
Result from Kenilworth Road
Luton Town&nbsp;5 (Watkins 41, Antwi 71, Morgan-Smith 74, Willmott 77, Crow 78)
Southport 1 (Brown 8)
FULL-TIME All over here at Kenilworth Road and the Town have picked up their first three points of the season thanks to a four-goal blitz in four second half minutes. Reaction, reports and so much more to come. COYH!
90 mins + 2 - Almost a chance for a sixth as AMS crosses from the left to find Crow but the striker's header flies into the Kenny End.
90 mins - Inside the final minute, five added.
88 mins - Another fine, flowing Hatters move is ended by the offside flag as AMS and Crow combine well. Two minutes left.
85 mins - Five minutes left for the Town to find a sixth. Possession the name of the game for the Hatters now, waiting for their chance.
83 mins - Seven left on the clock, the Hatters trying to score from all over now with Howells and Keane both having off target efforts from distance.
80 mins - 10 minutes to go now, all the Town now.
78 mins&nbsp;GOAL! TOWN 5-1 Southport - Southport collapsing all around us. Osano flys down the right, hangs up a perfect centre for DANNY CROW to head home from six yards.
77 mins GOAL! TOWN 4-1 Southport - With nothing on the ball drops to ROBBIE WILLMOTT 20 yards out who bangs a cracker beyond McMillan following Morgan-Smith's square pass. What a goal.
76 mins - All the Town now, dominating possession and with an extra man should be looking to score another one or two.
74 mins GOAL! TOWN 3-1 Southport - Lovely stuff, strong tackle from AMARI MORGAN-SMITH gets him away down the left, he cuts inside and sends a low shot that takes a nick of a defender past McMillan. 3-1.
71 mins GOAL! TOWN 2-1 Southport - The pressure pays off. From a Willmott corner - won by Watkins - Beckwith heads across goal and WILL ANTWI stabs home from close range to putt he Town ahead. Get in!
67 mins - Southport down to 10 men for the last 23 minutes as Akrigg pulls down Watkins, running through on goal. Second yellow, equals a red.
65 mins - Back come the Hatters, Morgan-Smith, Keane and Watkins eventually pop the ball off to Lawless who pings it high into the path of an onside Crow who chests it down and shoots wide. Unlucky.
64 mins - Almost a scare for the Town as Brown's cross from the right eludes Tyler but Antwi heads clear the danger. Phew.
62 mins - Ohh, agonisingly as the Hatters go&nbsp;close. Crow plays a lovely hooked pass into the path of Morgan-Smith who, with McMillan to beat, side-foots a shot wide, shaving the post.
60 mins - Second change for the Town on the hour as Amari Morgan-Smith replaces O'Connor on the right flank.
57 mins - Another half chance for Southport as Whalley tip-toes his way into the Town penalty area and flashes a shot wide into the Oak Road end.
55 mins - The attendance is 5,681.
54 mins - Almost half a sniff for Southport as Ledsham screws a shot over the bar from 18 yards out.
52 mins - Been little to report in the opening seven minutes of this first half but then Osano does well to beat Whalley, find Watkins who squares to O'Connor but the Town number 14 drags a left-foot shot wide of the post.
46 mins - And we're off for the second half, as the Town shoot towards the Kenilworth Road end. There's a change for Southport at the break. JP Kissock has been replaced by Russell Benjamin.
HALF-TIME And that's half-time and we're all square. A really funny first half and after going behind inside the first 10 minutes the Town go in level at half-time thanks to Adam Watkins' goal. Check back in 15 minutes for the second half updates. COYH.
45 mins - Chance, as the Town press for a second before the break. A corner from the left sees Willmott lay the ball off to Lawless who drives a low shot goalwards that takes several deflections before Southport clear.
41 mins GOAL! TOWN 1-1 Southport - It's been coming and boy, on his first league start ADAM WATKINS find the smallest space available in the bottom corner to find the net to grab an equaliser. Get in!
40 mins - Five minutes to the break now. All the Town now.
37 mins - And again. This time great play from Keane finds Crow who takes a touch to flick the ball up before sending a dipping shot goalwards that McMillan watches just, just clear the crossbar.
36 mins - Chances. And this is better stuff from the Town as Watkins runs at the heart of the Southport defence and lets fly with a left-foot shot that is blocked behind by Simon Grand. From the corner Antwi heads back across goal to O'Connor who turns to hit a shot that takes a deflection over.
35 mins - 10 minutes to the break now, can the Town find a leveller before the break?
31 mins - And Dance will not be taking any further action as he is led down the tunnel holding his head and is replaced by Danny Crow.
30 mins - 15 mintues to the break it's still 1-0 to the visitors. Stoppage in time with James Dance down with a head injury.
25 mins - Updates coming through a little slower than usual. Check out www.facebook.com/lutontown or twitter.com/LTFC_Official for quicker updates! We'll keep them going on this page anyway.
21 mins - First yellow of the afternoon as Steve Akrigg gets a card for hauling down O'Connor.
20 mins - Twenty on the clock done and not much more to report other than Southport lead.
15 mins - Absolutely pouring down with rain here at Kenilworth Road.
13 mins - Save for McMillan as the Town bite back. Willmott takes a short corner to Watkins who gives the Hatters' number 11 the ball back. He drops a shoulder and whacks a shot from the left-hand edge of the area that the visiting keeper has to paw away. Better.
11 mins - Frustration reigns at Kenilworth Road as the Hatters are struggling to get their game going. Southport, visibly lifted by their goal.
8 mins GOAL Town 0-1 SOUTHPORT - Uh oh, just like on Tuesday the Town find themselves behind. Visiting skipper Kevin Lee runs forward and with Howells exposed at left-back JONATHAN BROWN sneaks behind the defence to poke a shot past an exposed Mark Tyler.
5 mins - Not much to report in the opening five minutes, pretty even so far. The Town have Tyler in goal, Howells at left back, Osano at right back, Beckwith and Antwi at the centre of defensive, Lawless, Keane and Watkins in centre mid, Willmott left wing, Dance right wing and O'Connor up top.
1 mins - Early effort for the Town as they go in search of an early goal. Keane sprays the ball left to Wilmott who cuts inside and fires a shot just wide from 20 yards from the left-hand edge of the area.
1 min - And we're off as Southport get this BSBP game underway, they're shooting towards the Kenny End with the Town attacking the Oak Road end.
14:58 HERE THEY COME
Out come the two sides.
14:50 PRESS BOX PREDICTIONS
Andrew Barringer: 3-0 Luton, Matthew Parsfield: 2-0 Luton, Simon Pitts: 2-0 Luton, Mike Simmonds: 2-0 Luton, Mark Wood: 5-0 Luton, Ian Ryan: 3-1 Luton, Bill Cole: 3-1 Luton.
14:40 WEATHER WATCH
We've got a bit of rain here now at Kenilworth Road. Nowt heavy, though.
14:35 ONE WIN ALREADY
The Town's youth team won their first game of the season this morning with a 3-1 victory over Barnet. Jake Woolley, Alasan Ann and Musafa Mirzai hit the goals for Paul Driver's side who were 2-0 up at the break. Well done boys.
14:30 ALL IN A NAME
Three Town subs with double-barrelled names. Surely the first time that's happened?
14:15 THE TEAMS
Town: Tyler, Howells, Beckwith, Antwi, Osano, Watkins, Keane, Lawless, Willmott, Dance, O'Connor.
Subs: Morgan-Smith, Barnes-Homer, Crow, Asafu-Adjaye, K. Pilkington.
Southport: McMillan, Lee, Lever, Akrigg, Grand, Whalley, Gray, Brown, Smith, Ledsham, Kissock.
Subs: Nemes, Owens, Osborne, Benjamin, Ordish.
14:11 THREE CHANGES
Mark Tyler, Robbie Willmott and Adam Watkins all start.
13:40 ALMOST TIME
Sit tight, you'll have team news in 20 minutes.
13:10 ON THIS DAY
It's played nine, won three, drawn four, lost two on 20th August for the Hatters.
Last time the Town played on this date they were in Championship, losing to a last-minute super-strike from Dave Brammer at the Brittania Stadium against Stoke City. Dean Morgan scored the Town's goal.
All three of the wins have come at Kenilworth Road with the Hatters keeping a clean sheet in the process. A 3-0 League Cup victory over Bristol Rovers was the last game played at Kenilworth Road, back in 1996. Goals from Kim Grant, a Tony Thorpe penalty and David Oldfield secured a first leg lead before a crowd of 2,643.
In 1977 - when the Town were wearing a strip similar to today's kit - a solitary goal from Steve Buckley gave the Hatters an opening day win over Orient with 8,061 in the crowd.
It was another curtain raiser in 1966 when the Hatters triumphed 2-0 against Halifax Town. 6,148 watched goals from Gerry King and Bruce Rioch secure a win over the Shaymen.
1949 DIV2 WEST HAM UNITED H D 2-2
1951 DIV2 Sheffield United A L 0-3
1955 DIV1 Charlton Athletic A D 2-2
1960 DIV2 Huddersfield Town A D 1-1
1966 DIV4 HALIFAX TOWN H W 2-0
1977 DIV2 ORIENT H W 1-0
1994 LD1 Derby County A D 0-0
1996 LGEC BRISTOL ROVERS H W 3-0
2005 CHMP Stoke City A L 1-2
12:45 PITCH IN
On our official Facebook has&nbsp;a photo of the Kenilworth Road pitch at the minute. As the picture shows, it's a bit overcast still.
12:20 WEATHER WATCH
Intermittent sunshine, warm but plenty of cloud in the sky here in LU4.
11:30 GETTING IT RIGHT...
...that was the headline on lutontown.co.uk yesterday as Town boss Gary Brabin told us that he's looking to get the Hatters' season off and underway with a first victory.
The Town have only played one game and somehow, somehow, could not make their possession and chances count in their season opener against Forest Green Rovers on Tuesday, the manager feels frustration - like us all.
Naturally there is disappointment when you don't win at home and his side's failure to collect all three points meant that there is room for improvement. Room to get it right.
Southport stand in his way this afternoon. His former employers have the sad demise of Rushden &amp; Diamonds to thank for being able to meet the Town this afternoon. Relegated last season, Liam Watson's side have a second bite of the cherry in non-league's top flight. A trip to Kenilworth Road instead of journeys to Vauxhall Motors and Bishop's Stortford.
Of course, as if they don't need reminding, the Sandgrounders were soundly beaten on their last visit to LU4. A 6-0 drubbing still hurts, and Watson and co. will be all out to avenge that hammering and continue a solid start to the current campaign where they have drawn twice from their opening to fixture.
Brabin and the Hatters will be hoping for a repeat this afternoon and, although the chances of lightening striking twice are a 55/1 chance with Coral, everyone will be expecting a home win this afternoon...
...and then everything will be all right.
Well, whatever happens at Kenilworth Road this afternoon, and throughout the season, your official website will have everything covered: every step of the way.
If you can't make the match then we'll have all the goals and incidents as it happens live with the usual news in the run-up to kick-off with team line-ups and plenty of chat as your official website has, as ever, the usual updates keeping you bang up-to-date with all the action - and in a number of ways.
There's none of those boring ball-by-ball "defensive thrown-in taken by Luton left-back" updates as we continue to and bring you an updated and detailed text commentary. This is a great way to keep in touch and has been popular to those supporters not able to get to a computer or a radio as the service is also available and is updated live on our WAP site.
On Hatters Player you all have access to our live commentary. Remember, Player is available as ever which means you all have access to our live commentary. If you haven't heard it yet then where you have been?
It's still brought to you by Simon "Statto" Pitts but he's got company this time! The DiverseFM team have collaborated with BBC Three Counties radio and the Club to bring you the Luton Town Show.
Following the final whistle we'll have all the reaction from the men that matter this after, bringing you exclusive video content from Gary Brabin and from the dressing room.
We'll have plenty of content to keep you interested as we'll have all of the post-match reaction from Brabs as well as match action from Gareth Owen to follow after the final whistle. Be sure to check out www.hatterspics.co.uk - our online image library. Like a picture you see and fancy having that on a mug? Well, fancy no more - with Hatters Pics it's a reality.
Remember, we want you to get in touch. Join the updates and get in touch. Email email@example.com and we'll pick the best comments to go live on the site during our live updates.
Don't forget we're also on twitter and Facebook so feel free to interact with your fellow fans online.
Enjoy the game.